In literature several methodologies based on artificial intelligence techniques (neural networks, genetic algorithms and fuzzy-logic) have been proposed as alternatives to conventional techniques to solve a wide range of problems in various domains. The purpose of this work is to use neural networks and genetic algorithms for the prediction of the optimal sizing coefficient of Stand-alone Photovoltaic (SAPV) systems in remote areas when the total solar radiation data are not available. A database of total solar radiation data for 40 sites corresponding to 40 locations in Algeria, have been used to determine the iso-reliability(sizing) curves of a SAPV system (CA, CS) for each site. Initially, the genetic algorithm (GA) is used for determining the optimal coefficient (CAop, CSop) for each site by minimizing the optimal cost (objective function). These coefficients allow the determination of the number of PV modules and the capacity of the battery. Subsequently, a feed-forward neural network (NN) is used for the prediction of the optimal coefficient in remote areas based only on geographical coordinates. For this, 36 pairs have been used for the training of the network and 4 pairs have been used for testing and validation of the network. The simulation results have been analyzed and compared with conventional methods in order to show the importance of the proposed methodology. This methodology has been applied for Algerian location, but it can be generalized in the World. The Matlab (R) Ver. 7 has been used for this simulation.