ELECTRICA

FUNCTION OF VOLTAGE-GATED IONIC CHANNELS

1.

Zonguldak Karaelmas University, Engineering Faculty, Department of Electrical and Electronics Engineering, 67100 Zonguldak, Turkey

2.

Yıldız Technical University, Electrical and Electronics Engineering Faculty, 80750 Besiktas, Istanbul, Turkey

ELECTRICA 2004; 4: 1091-1104
Read: 793 Downloads: 508 Published: 28 December 2011

In this paper, we investigate dynamics of voltage-gated ionic channels which are of great importance in integrating the  information received by neurons. Understanding  of dynamical behavior of voltage-gated ionic channels plays a major role for determining underlying mechanism of spike activity and predicting the neuronal behavior. Investigation is carried out based on Hodgkin-Huxley (H-H)  mathematical formalism. Ionic channel gate model is discussed briefly. Relaxation phenomenon is studied in the gate variables.  Then effects of temperature on dynamics of gate variables are examined. Finally voltage-clamped simulations are carried out to determine their dynamic behaviors based on squid giant axon.

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EISSN 2619-9831